Today, we’re talking about something every injector needs to know: Letybo vs. Botox.
There’s a new neuromodulator in town — and it’s ready to challenge what we’ve known for years. Whether you’re a patient, doctor, nurse practitioner, PA, RN, or dentist in the aesthetic world, you’ll want to understand how Letybo stacks up against the gold standard Botox® — and if it makes sense for your practice.
Let’s get into it.
Quick Overview: What Are We Comparing?
- Botox® (onabotulinumtoxinA)
The original, the legend — over 20 years of clinical use, name brand recognition, consistent performance. - Letybo (letibotulinumtoxinA-wlbg)
The newest FDA-approved botulinum toxin A (2024), from Hugel, already popular in Asia and Europe. Now fully commercialized in the U.S.
Both are purified botulinum toxin type A products aimed at treating glabellar lines (the frown lines between the brows) — and off-label, we know both are used across the face and neck.
Efficacy: How Well Do They Work?
Here’s the good news — both products perform at a high level.
In clinical trials (citing PubMed data on Letybo and Botox), Letybo proved non-inferior to Botox for:
- Reducing wrinkle severity
- Speed of onset
- Duration of effect
- Patient satisfaction
Letybo Clinical Highlights:
- Improvements seen as early as day 3 post-injection
- Maximum effect around day 7–14
- Results lasting up to 4 months
- High responder rates (≥1-point improvement in glabellar line severity in 95%+ of patients at day 30)
Botox Clinical Highlights:
- Improvements starting day 2–4
- Peak effects around day 7–14
- Results lasting 3–4 months depending on dose and muscle strength
Bottom Line:
In terms of clinical results? They’re neck and neck.
Both create beautiful smoothing of dynamic lines with natural-looking outcomes when injected correctly.
Patient Experience: How Does It Feel?
Patients today want:
- Natural results (no frozen faces)
- Fast onset
- Longevity without looking overdone
Both products meet these demands, but early reports from U.S. injectors suggest Letybo feels slightly “lighter” in its effect — a soft, natural relaxation of muscles rather than a heavy, locked-in feel.
Some patients notice smoother transitions between treated and untreated areas with Letybo compared to Botox, which can be helpful for facial balancing.
Diffusion and Spread: Precision Matters
Botox is famous for its predictability and controlled spread.
Letybo appears to have a similar, slightly tighter spread profile, which can help when treating small muscles or delicate areas like crows’ feet or microtox applications.
👉 Translation for injectors:
If you’re using microdoses, delicate feathering, or performing advanced techniques, you’ll feel right at home with Letybo.
Safety Profile: Is It Safe?
Both Botox and Letybo are well-studied, with strong safety records.
In the Letybo trials:
- The most common side effects were headache and eyelid ptosis, occurring at rates similar to Botox (2–5%).
- No new safety signals compared to established neuromodulators.
Again, technique matters — precise injection depth and dosing can minimize risks in both cases.
Cost: What About Pricing?
While pricing structures vary by region and distributor, early signs point to Letybo offering a competitive cost advantage over Botox for clinics.
For practices, this could mean:
- Better profit margins
- More pricing flexibility for patients
- Increased accessibility for newer patients hesitant to try injectables
FDA Indications and Off-Label Use
Officially:
- Botox and Letybo are both FDA-approved for glabellar lines.
Off-label:
Experienced injectors are using both across the forehead, crows’ feet, masseter muscles, neck bands, and more.
(As always, off-label use should be informed by best clinical practices and patient consent.)
Which One Should You Get or Offer?
Here’s my take:
✔️ If you already have a strong Botox patient base — Letybo offers a seamless transition if you’re looking for a competitive option.
✔️ If you’re opening a new medical spa or expanding your neuromodulator menu, offering both can position you as a modern, versatile injector.
✔️ If you’re price-sensitive or catering to a younger, newer demographic, Letybo could give you a huge advantage.
✔️ Patients who want ultra-soft, natural, subtle results may love Letybo.
Final Thoughts: Botox or Letybo?
Both are phenomenal tools in our injector toolbox.
Botox isn’t going anywhere — it’s the gold standard. But Letybo brings fresh energy, competitive pricing, and beautiful natural results to the market.
I believe Letybo is a smart addition for aesthetic professionals who want to stay ahead, offer choice, and optimize outcomes.
👉 Remember, it’s not just about the product — it’s about skillful injection, customized dosing, and patient education.
