Today, we’re diving into something exciting that’s just hit the U.S. aesthetics market: Letybo (LetibotulinumtoxinA). This is the new neuromodulator that’s been getting a lot of attention, and for good reason. If you’re a patient, doctor, nurse practitioner, PA, RN, or dentist offering injectables — or planning to — this is something you’ll want on your radar. Let’s break it all down.
What is Letybo?
Letybo is a botulinum toxin type A — just like Botox®, Dysport®, Xeomin®, Daxxify®, and Jeuveau®. But it’s not just another copycat.
Manufactured by Hugel, a major player in aesthetics (especially throughout Asia and Europe), Letybo has been newly FDA-approved for treating moderate to severe glabellar lines (those stubborn “11s” between the brows).
According to their FDA package insert (2024) and multiple PubMed studies, Letybo offers high purity, reliable efficacy, and a very natural, soft finish — the look our patients are asking for!
How Letybo Compares to Botox
Now, here’s where it gets interesting.
In head-to-head clinical trials, including research published on PubMed, Letybo demonstrated non-inferior results to Botox® for glabellar lines — meaning, similar or better wrinkle reduction, similar onset of action, and similar duration of effect.
Key clinical points:
- Onset of effect: Improvements were seen as early as day 3 post-injection.
- Peak effect: Maximal improvement typically around day 7 to 14.
- Duration: Results lasted around 3 to 4 months — comparable to Botox®.
- Safety: Adverse events were mild and rare, similar to other neuromodulators.
Takeaway: If you’re familiar with Botox®, you’re going to feel very comfortable injecting Letybo.
Source: PubMed LetibotulinumtoxinA studies.
What’s Unique About Letybo?
✔️ High Purity:
Hugel uses a patented purification process, resulting in fewer complexing proteins. Translation: potentially lower risk of antibody formation over time.
✔️ Smooth, Soft Finish:
Patients report a softer, more natural result — not the “frozen” look. Ideal for modern aesthetics where less is more.
✔️ Optimized Diffusion:
The product is designed to have controlled spread, meaning you can finesse your injection patterns for beautiful, natural results — whether it’s glabella, crow’s feet, or forehead lines.
✔️ Backed by Global Success:
Letybo has already been widely used in Asia and Europe — with millions of treatments done before arriving in the U.S.
Hugel’s international reputation gives it serious credibility.
Dosage and Reconstitution
For treating glabellar lines, the FDA-approved protocol for Letybo recommends:
- Dose: 20 Units total
- Injection Sites: 5 standard glabellar points (similar to Botox®)
- Dilution: Reconstituted with 2.5 mL of preservative-free saline for a concentration of 4 U per 0.1 mL.
Pro Tip:
From my clinical perspective — and similar to what we see with Botox® — you may adjust slightly based on muscle strength, forehead height, or male vs. female anatomy.
How It’s Being Positioned in the U.S. Market
Benev Company Inc. is bringing Letybo to the U.S., and they’re positioning it as a premium option — not as a discount or “budget” toxin.
In fact, their official press releases emphasize the clinical equivalence to Botox® and the demand for natural-looking outcomes.
It’s going to sit right alongside the other heavyweights — offering a new choice for injectors who are focused on artistry and precision.
Sources:
Should You Offer Letybo in Your Practice?
If you’re serious about staying ahead in aesthetics — absolutely consider it.
Here’s why:
- Patients love options.
- Natural-looking results are in demand.
- New products generate buzz and attract fresh inquiries.
- It’s great to have alternatives for patients who may not have loved other neuromodulators.
But remember: Any new product comes with a learning curve.
If you’re already experienced with Botox® and Dysport®, you’ll find the transition into Letybo seamless — just fine-tune your reconstitution and dosing habits.
Final Thoughts
Letybo is a fresh, exciting addition to our neuromodulator toolbox.
With its high purity, reliable efficacy, and natural-looking results, it’s a product you’ll want to get familiar with — because patients will start asking about it.
I’m excited to see how injectors incorporate Letybo into their artistry.
Stay tuned — I’ll be sharing more clinical pearls as we get hands-on with this new player in the U.S. market.
See you soon — and as always, keep raising the bar in aesthetics!
