If you’re in aesthetics, you know 2025 is a huge year.
The FDA has now approved FIVE neuromodulators for reducing wrinkles between the brows — the frown lines. That’s Botox®, Dysport®, Xeomin®, Jeuveau®, and now the newcomer: Letybo®.
Today, I’m going to break them down for you.
We’ll go over what makes each one different, what the research says — and yes, we’ll dive into why I’m personally excited about Letybo.
(Disclaimer: This blog is part of the Letybo Challenge. There is a financial relationship. But you’ll still get my honest, clinical view, as always.)
First, What Are These Neurotoxins?
Here’s the cheat sheet:
| Name | Molecule | Description |
|---|---|---|
| Botox | ONAbo-A | The classic. Gold standard. |
| Dysport | ABObo-A | A little faster onset. |
| Xeomin | INCO-A | “Naked” toxin — no accessory proteins. |
| Jeuveau | PRAbo-A | Botox twin, priced to compete. |
| Letybo | LETIbo-A | Newest player. Purified. Smooth performance. |
BotulinumtoxinA (BoNT-A) is the actual active molecule that relaxes muscles.
The prefixes — “Ona,” “Abo,” “Inco,” “Pra,” and now “Leti” — reflect tiny differences in how they are produced, purified, and stabilized.
These slight differences can impact:
- Onset speed
- Duration
- Spread (diffusion)
- Patient feel
Which One Is Better?
Big question. I get it all the time.
Instead of opinions, let’s look at the evidence.
Here’s a summary of real studies (PubMed-sourced) comparing these products:
| Title | Conclusion | Winner |
|---|---|---|
| A mixed treatment comparison (MTC) of Botox, Dysport, Xeomin for cervical dystonia | No significant efficacy difference between Botox, Dysport, Xeomin. | None |
| Conversion Ratio between Botox, Dysport, and Xeomin | ONA and INCO have 1:1 efficacy; ABO needs about 2.5–3x units. | None |
| A Randomized Trial of Dynamic Strain Reduction | Products not interchangeable in muscle strain at same doses. | None |
| Onset/Duration Study for Glabellar Lines | Xeomin had faster onset and longer duration than Botox and Dysport. | Xeomin |
| Botox vs. Dysport Face Wrinkle Study | No significant difference in forehead, glabella, crow’s feet. | None |
👉 Bottom line?
No clear champion.
Each brand has its slight nuances, but in skilled hands, they all work beautifully.
Now — Where Does Letybo Fit In?
Letybo (letibotulinumtoxinA-wlbg) received full FDA approval in 2024 for treating moderate-to-severe glabellar lines after strong clinical trials.
Let’s break it down:
Key Letybo Highlights:
- Purified BoNT-A similar to Botox
- Fast onset: noticeable results by Day 3
- Peak effect: around Day 7–14
- Duration: ~4 months
- Clinical success: 95%+ patients had at least a 1-point improvement at Day 30
- Safety: Low immunogenicity, minimal adverse events
What Makes Letybo Different?
- Smoother spread across injection sites (great for natural results)
- Less protein load — meaning possibly less chance of antibody formation
- Backed by Hugel and Croma Pharma — huge in Asia and Europe
- Fully commercialized in U.S. now with Benev
Patient Feel?
Early feedback shows very soft, natural movement — less chance of heaviness, especially important in dynamic facial areas.
Why I’m Paying Attention to Letybo
You know me — I’m all about:
- Natural aesthetics
- Longevity
- Minimizing resistance risks
Letybo checks those boxes.
Plus, having a new option forces innovation in pricing, support, and technique — and that’s great for both injectors and patients.
Remember: mastering the nuances between products is what separates good injectors from great ones.
Quick Clinical Tips: Using Letybo
✅ Dosing:
Letybo’s dosing is designed 1:1 with Botox for glabella.
(Example: 20 units total for glabellar lines.)
✅ Technique:
Same 5-point glabellar injection pattern as Botox.
✅ Dilution:
Reconstitution guidelines are similar (e.g., 2.5mL per 100U vial), but always verify the vial instructions.
✅ Patient Counseling:
Manage expectations: onset around Day 3, peak by Day 7–14, results last up to 4 months.
Final Thoughts: Should You Try Letybo?
Here’s our bottom line:
- If you love Botox, you’ll feel at home with Letybo.
- If you want softer transitions, less stiffness, faster onset — it’s worth adding to your menu.
- It’s competitively priced and strategically supported in the U.S.
⚡Bonus Tip:
Early adopters often get the best incentives and patient buzz when new products launch.
Conclusion
2025 is shaping up to be the most exciting year yet for neuromodulators.
With Botox, Dysport, Xeomin, Jeuveau, and now Letybo, your aesthetic toolbox is bigger and better than ever.
Master them all. Understand the differences. Tailor your approach.
And remember — in the end, it’s not the product.
It’s your technique that transforms lives.
